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Previous Volume 351:2773-2774 December 23, 2004 Number 26 Next

Estrogen Receptor in Prostate Cancer

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the Prostate Cancer Prevention Trial,¹ more than 18,000 healthy volunteers were randomly assigned to receive either finasteride (5 mg daily) or placebo. The incidence of prostate cancer in the finasteride group was 18.4 percent, as compared with 24.4 percent in the placebo group. A bigger surprise was that the incidence of tumors with a Gleason grade of 7, 8, 9, or 10 was higher in the finasteride group than in the placebo group (37.0 percent vs. 22.2 percent, P<0.001), meaning that there were more cases of aggressive cancer with finasteride than there were with placebo.¹

We . . . [Full Text of this Article]

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• Jayachandran, J., Freedland, S. J. (2008). Prevention of Prostate Cancer: What We Know and Where We Are Going. American Journal of Men's Health 2: 178-189 [Abstract]  
• Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Strom, A., Treuter, E., Warner, M., Gustafsson, J.-A. (2007). Estrogen Receptors: How Do They Signal and What Are Their Targets. Physiol. Rev. 87: 905-931 [Abstract] [Full Text]  
• Taylor, R. A, Cowin, P., Couse, J. F., Korach, K. S., Risbridger, G. P. (2006). 17{beta}-Estradiol Induces Apoptosis in the Developing Rodent Prostate Independently of ER{alpha} or ER{beta}. Endocrinology 147: 191-200 [Abstract] [Full Text]  
• Koehler, K. F., Helguero, L. A., Haldosen, L.-A., Warner, M., Gustafsson, J.-A. (2005). Reflections on the Discovery and Significance of Estrogen Receptor {beta}. Endocr. Rev. 26: 465-478 [Abstract] [Full Text]