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Previous Volume 351:215-216 July 15, 2004 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The primary cause of death from cancer is the progressive growth of metastases that are resistant to conventional therapies. The site of metastasis from primary neoplasms is not random. Indeed, in 1889, Stephen Paget proposed that the process of metastasis did not occur by chance but, rather, that certain favored tumor cells (the "seed") had a special affinity for the growth-enhancing milieu within specific organs (the "soil"). He concluded that metastases developed only when the seed and the soil were compatible. Our current version of the seed-and-soil hypothesis consists of two principles. First, neoplasms are heterogeneous: they consist of cells . . . [Full Text of this Article]

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From the Departments of Cancer Biology (I.J.F., L.M.E.) and Surgical Oncology (L.M.E.), University of Texas M.D. Anderson Cancer Center, Houston.

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