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Previous Volume 351:250-259 July 15, 2004 Number 3 Next

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ABSTRACT

Background The growth of most tumors depends on the formation of new blood vessels. In contrast to genetically unstable tumor cells, the endothelial cells of tumor vessels are considered to be normal diploid cells that do not acquire mutations.

Methods Using a combined immunohistochemical and fluorescence in situ hybridization assay, we examined the endothelial cells in 27 B-cell lymphomas for cytogenetic alterations that are known to be present in the lymphoma cells.

Results We found that 15 to 85 percent (median, 37 percent) of the microvascular endothelial cells in the B-cell lymphomas harbored lymphoma-specific chromosomal translocations. In addition, numerical chromosomal aberrations were shared by the lymphoma cells and the endothelial cells.

Conclusions Our findings suggest that microvascular endothelial cells in B-cell lymphomas are in part tumor-related and therefore reflect a novel aspect of tumor angiogenesis.

Source Information

From the Institutes of Pathology (B.S., A.C., D.H.) and Medical and Chemical Laboratory Diagnostics (M.E., O.W., I.S.) and the Department of Internal Medicine I, Division of Hematology (U.J.), Center of Excellence in Clinical and Experimental Oncology, Lymphoma Program, Medical University of Vienna, Vienna General Hospital, Vienna.

Address reprint requests to Dr. Chott at the Institute of Pathology, Vienna General Hospital, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria, or at andreas.chott{at}akh-wien.ac.at or to Dr. Wagner at oswald.wagner{at}meduniwien.ac.at.

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Endothelial Cells in B-Cell Lymphomas
True L. D., Swisshelm K., Streubel B., Wagner O., Chott A.
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N Engl J Med 2004; 351:2019, Nov 4, 2004. Correspondence

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