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Previous Volume 351:268-277 July 15, 2004 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations.

A 52-year-old-woman with no history of venous thromboembolism presents with a four-day history of discomfort in her left calf. Proximal deep-vein thrombosis is diagnosed by compression ultrasonography. How should her case be managed?

The Clinical Problem

The annual incidence of venous thromboembolism is approximately 0.1 percent; the rate increases from 0.01 percent among persons in early adulthood to nearly 1 percent among those who are . . . [Full Text of this Article]

Strategies and Evidence

Diagnosis

Initial Therapy

            Unfractionated Heparin

            Low-Molecular-Weight Heparins

            Thrombolytic Therapy

Long-Term Therapy

Duration of Anticoagulation

Areas of Uncertainty

The Role of Reduced-Intensity Anticoagulation

New Anticoagulants

Testing for Thrombophilia

Prevention of the Post-Thrombotic Syndrome

Guidelines

Recommendations

Source Information

From the Department of Medicine, McMaster University, Hamilton, Ont., Canada.

Address reprint requests to Dr. Bates at the Department of Medicine, McMaster University, HSC 3W11, 1200 Main St. W., Hamilton, ON L8N 3Z5, Canada, or at batesm@mcmaster.ca.

Related Letters:

Deep-Vein Thrombosis
Korenfeld M. S., Vedantham S., Khilnani N., Min R., Bates S. M., Ginsberg J. S.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:2133-2134, Nov 11, 2004. Correspondence

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