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Previous Volume 351:295-298 July 15, 2004 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The analyses presented by Danesh and colleagues (April 1 issue)¹ do not support their conclusion that C-reactive protein is only a moderate risk factor for coronary heart disease. First, their comparison of risk factors relies on the odds ratio for the comparison of the top and bottom thirds of observed distributions in their population. Such strategies yield arbitrary results that can vary greatly among populations with different risk-factor distributions.² Cholesterol levels in Reykjavik, Iceland, in 1967 were far higher than current U.S. levels of cholesterol,³ whereas the levels of C-reactive protein were lower than current U.S. levels,⁴ . . . [Full Text of this Article]

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