From the 1960s until the mid-1990s, fluorouracil was the primarychemotherapeutic agent available for the treatment of colorectalcancer. During the past decade, the Food and Drug Administration(FDA) has approved five new drugs for metastatic colorectalcancer. Irinotecan (approved in 1996) and oxaliplatin (2002)are cytotoxic agents that interfere with DNA replication, andcapecitabine (1998) is an oral formulation of fluorouracil.This spring, the monoclonal antibodies bevacizumab and cetuximab,targeting vascular endothelial growth factor and epithelialgrowth factor receptor, respectively, were approved by the FDAfor use in conjunction with cytotoxic regimens.
From the Memorial Sloan-Kettering Cancer Center, New York.
Related Letters:
Cetuximab in Colon Cancer
Holmer A. F., Martin M. J., Costa A. F., Sander G. B., Picon P. D., Schrag D., Chau I., Cunningham D.
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N Engl J Med 2004;
351:1575-1576, Oct 7, 2004.
Correspondence
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