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Clinical Implications of Basic Research
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Volume 351:393-394 July 22, 2004 Number 4
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Death, Destruction, and the Proteasome
William Patrick Tansey, Ph.D.

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Apoptosis is an amazing thing. By endowing cells with the ability to kill themselves, nature allows entire organisms to be spared at the expense of a few dysfunctional, damaged, or malignant cells. But this strategy comes at a price — mechanisms must exist to keep the apoptotic machinery inactive under normal conditions and quickly activate it when the cell must die. New work by Sun and colleagues1 reveals that the switch to rapid and efficient cell death unexpectedly involves the destruction of the highest-profile protease within the cell — the 26S proteasome.

Without a doubt, proteolysis is one of the . . . [Full Text of this Article]


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From Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.



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