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Previous Volume 351:395-397 July 22, 2004 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Hamrahian et al. (April 15 issue)¹ describe a technique for measuring free cortisol concentrations that is technically difficult, likely to be expensive, and not widely available. They do not correlate the measured serum free cortisol value with the free cortisol index to determine the comparability of the two measurements. They conclude that measuring serum free cortisol concentrations in critically ill patients with hypoproteinemia may help prevent unnecessary glucocorticoid therapy but do not provide any data regarding the use of glucocorticoid therapy in critically ill patients. The appropriate cortisol response to severe sepsis and septic shock is highly . . . [Full Text of this Article]

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