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Previous Volume 351:422-423 July 29, 2004 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The current standard treatment for chronic hepatitis C is the combination of pegylated interferon alfa and ribavirin, a synthetic guanosine analogue. In the pegylated form of interferon, the interferon alfa molecule is linked to a polyethylene glycol molecule to ensure sustained interferon concentrations after single weekly injections. Pegylated interferon alfa potently inhibits the replication of hepatitis C virus (HCV) and has immunomodulatory properties that probably accelerate the clearance of infected cells. Ribavirin exerts a weak and transient early antiviral effect and acts primarily by preventing relapses during and after therapy in patients who have had an initial response. Ribavirin's mechanisms . . . [Full Text of this Article]

Source Information

From the Department of Virology, INSERM Unité 635, Henri Mondor Hospital, University of Paris XII, Créteil, France.

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