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Volume 351:510 July 29, 2004 Number 5
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Case 15-2004: Cancer Therapy and Sperm Banking

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by Ballen, K. K.
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To the Editor: With regard to Case 15-2004 (May 13 issue),1 I would like to add an important point to the discussion of the impact of cancer therapy on fertility. Although the authors correctly note the association between testicular irradiation and the impaired synthesis of testosterone, they do not comment on the greater threat to spermatogenesis posed by the high doses of testicular radiation (18 Gy) and cyclophosphamide that were used to treat this patient. Doses of radiation above 4 Gy lead to azoospermia in most men,2 and alkylating agents such as cyclophosphamide are a common cause of infertility.3 Because . . . [Full Text of this Article]



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