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Correspondence
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Volume 351:511-512 July 29, 2004 Number 5
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Transient Improvement of Spinocerebellar Ataxia with Zolpidem

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To the Editor: There is currently no effective pharmacologic treatment for spinocerebellar ataxia. We describe a family of five patients, four of whom had clinical improvement within one hour after the ingestion of zolpidem (10 mg). The diagnosis of spinocerebellar ataxia type 2 was confirmed by molecular analysis. Analysis of DNA for CAG repeat expansions in the SCA1, 2, 3, 6, and 7 genes revealed expansion of CAG repeats at the SCA2 locus.

Patient 1, a 49-year-old man with titubation, dizziness, and loss of balance from the age of 34 years, had deteriorating speech and handwriting. Cerebellar signs included moderate . . . [Full Text of this Article]



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