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Volume 351:524 August 5, 2004 Number 6
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Producing Penicillin
Phillip I. Lerner, M.D.

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 by Wenzel, R. P.
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Although Alexander Fleming discovered penicillin in 1928, the substance was largely ignored until scientists at Oxford University rediscovered it in the early 1940s. Because of World War II, with its air raids and threat of German invasion, the Oxford group sought help in the United States. The meagerness of the supplies of penicillin dictated its slow evolution as a chemotherapeutic agent. Its early history involved attempts to synthesize the chemical structure and to invent ways to produce larger quantities to meet the rapidly growing demand. As more and more types of infections were found to be susceptible to penicillin, it . . . [Full Text of this Article]


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From the Division of Infectious Diseases, University Hospitals of Cleveland, Cleveland.


Related Letters:

Production of Penicillin
Tishler P. V., Lerner P. I.
Extract | Full Text | PDF  
N Engl J Med 2005; 352:97, Jan 6, 2005. Correspondence

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