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Previous Volume 351:528-530 August 5, 2004 Number 6 Next

TGF- Signaling, Tumor Suppression, and Acute Lymphoblastic Leukemia

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The emergence of a single cancer cell is an extremely complex process that depends not only on the escape of a normal cell from growth-control mechanisms but also on the ability of the abnormal cell to bypass the numerous molecular checkpoints that control its propagation. Among these barriers against abnormal cells is a diverse family of proteins called tumor suppressors, one of which is transforming growth factor (TGF-). This polypeptide initiates a signaling pathway that suppresses the early development of cancer cells in a number of different cell lineages.

TGF- exists in three versions, or isoforms: TGF-1, 2, . . . [Full Text of this Article]

Source Information

From the Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tenn.

This article has been cited by other articles:

• Li, H., Xu, D., Li, J., Berndt, M. C., Liu, J.-P. (2006). Transforming Growth Factor beta Suppresses Human Telomerase Reverse Transcriptase (hTERT) by Smad3 Interactions with c-Myc and the hTERT Gene. J. Biol. Chem. 281: 25588-25600 [Abstract] [Full Text]