The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
A correction has been published: N Engl J Med 2004;351(15):1582.

Perspective
PreviousPrevious
Volume 351:748-750 August 19, 2004 Number 8
NextNext

Female Development — All by Default?
Ieuan A. Hughes, M.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
- PDF
-PDA Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited
-E-mail When Letters Appear

More Information
-Related Article
-Related Article
by Biason-Lauber, A.
-PubMed Citation
It has been an indisputable fact that the constitutive sex in mammalian fetal development is female. Furthermore, a functioning ovary is not required for the female phenotype, whereas a testis is mandatory for male development. More than 50 years after Jost performed experiments in rabbit embryos in which castration was followed by testis engraftment, his observations remain a beacon of clarity illuminating the mechanism of fetal sexual differentiation — the physical phenotype consistent with male or female sex.1

Another indisputable fact of mammalian fetal sexual development is the morphogenesis of a bipotential gonad in the genital ridge, dual internal genital . . . [Full Text of this Article]


Source Information

From the Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.