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Previous Volume 351:822-824 August 19, 2004 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Human geneticists have been on a long joyride. The power of contemporary genetics and genomics has allowed us to identify the specific causal gene in a dizzying variety of mendelian (single-gene) and chromosomal disorders that affect every single human organ system.¹ This information has transformed our knowledge of the pathophysiology of genetic diseases in humans, including cleft lip with or without involvement of the palate.

Three specific genes are known to harbor mutations that lead to cleft lip or palate and additional anomalies: MSX1 (also known as HOX7), which encodes muscle-segment–specific homeobox 1²; FGFR1, which encodes fibroblast growth . . . [Full Text of this Article]

Source Information

From the McKusick–Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore.

This article has been cited by other articles:

• Huang, Y., Wu, J., Ma, J., Beaty, T.H., Sull, J.W., Zhu, L., Lu, D., Wang, Y., Meng, T., Shi, B. (2009). Association between IRF6 SNPs and Oral Clefts in West China. JDR 88: 715-718 [Abstract] [Full Text]  
• Vieira, A.R. (2008). Unraveling Human Cleft Lip and Palate Research. JDR 87: 119-125 [Abstract] [Full Text]  
• Srichomthong, C, Siriwan, P, Shotelersuk, V (2005). Significant association between IRF6 820G->A and non-syndromic cleft lip with or without cleft palate in the Thai population. J. Med. Genet. 42: e46-e46 [Abstract] [Full Text]