If ever there were a perfect marriage of drug with disease itmight be between statins and atherosclerosis. At first the relationshipwas simple: statins inhibited synthesis of the cholesterol thatcontributed to atheroma, and less cholesterol meant less atheroma.Just as married couples often adapt to each other, so it iswith statins and atheroma, or to be more precise, an increasedunderstanding of their relationship has revealed an apparentadaptation. Atherosclerosis is now recognized to have a notableinflammatory component, and in parallel, statins appear to inhibitinflammatory processes directly. Rheumatologists pondering thisphenomenon from the outside (and . . . [Full Text of this Article]
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From the Centre for Rheumatology, Department of Medicine, University College, London.
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