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Previous Volume 352:85-86 January 6, 2005 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Why are brain neurons so much more susceptible to ischemic injury than, say, muscle or skin tissue? A clue is provided by work showing that the activation of neuronal acid-sensing ion channel 1 (ASIC1) can lead to neuronal death.^1,2,3 A recent study by Xiong et al.³ places this observation in the context of stroke by showing that the activation of ASIC1 during the metabolic acidosis accompanying experimental stroke contributes substantially to subsequent brain injury.

Excessive loading of calcium into neurons through N-methyl-D-aspartate (NMDA) receptors and voltage-dependent calcium channels is thought to be one of the triggers of neuronal injury . . . [Full Text of this Article]

Source Information

From the Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (M.B.); and the Department of Pharmacology, Emory University School of Medicine, Atlanta (M.B., R.D.).

This article has been cited by other articles:

• Hey, J. G., Chu, X.-P., Seeds, J., Simon, R. P., Xiong, Z.-G. (2007). Extracellular Zinc Protects Against Acidosis-Induced Injury of Cells Expressing Ca2+-Permeable Acid-Sensing Ion Channels. Stroke 38: 670-673 [Abstract] [Full Text]  
• Pignataro, G., Simon, R. P., Xiong, Z.-G. (2007). Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain 130: 151-158 [Abstract] [Full Text]  
• Chu, X.-P., Close, N., Saugstad, J. A., Xiong, Z.-G. (2006). ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents.. J. Neurosci. 26: 5329-5339 [Abstract] [Full Text]  
• Donier, E., Rugiero, F., Okuse, K., Wood, J. N. (2005). Annexin II Light Chain p11 Promotes Functional Expression of Acid-sensing Ion Channel ASIC1a. J. Biol. Chem. 280: 38666-38672 [Abstract] [Full Text]