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Previous Volume 352:1162-1163 March 17, 2005 Number 11 Next

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Edited by Peter Curtis-Prior. 634 pp., illustrated. Chichester, England, John Wiley & Sons, 2004. $367.95. ISBN 0-471-48984-0.

Peter Curtis-Prior's 57-chapter book took five years to prepare and contains contributions from 106 authors. Its length reflects how ubiquitous essential fatty acids and their metabolites are in human and animal tissues. The clinical implications of eicosanoids — molecules derived from fatty acids — are innumerable. Eicosanoids, the topic of this book, are autacoids — short-lived, physiologically active endogenous substances that act locally in response to injury and then undergo rapid inactivation. Histamine, bradykinin, serotonin, and angiotensin are also autacoids. The word "autacoid" is derived from the Greek autos ("self") and akos ("medicinal agent" or "remedy"). All eicosanoids are biotransformation . . . [Full Text of this Article]

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