Improvements in immunosuppressive therapy during the past decadehave brought us closer to the day when long-term acceptanceof organ allografts will be routine. These achievements, however,have run up against an important limitation: death of the recipientfrom cardiovascular disease, infection, and cancer.1 As comparedwith an age-matched healthy population or with patients undergoingdialysis, organ-transplant recipients have an increased incidenceof cancer; one study found that after 20 years of immunosuppressivetherapy, 40 percent of recipients had cancer.2 Further burdensare to be expected in an aging population of transplant recipientswith well-functioning allografts.
From the Institut de Transplantation et de Recherche en Transplantation, INSERM Unité 463, Nantes University, Centre Hospitalier Régional Universitaire de Nantes, Nantes, France.
This article has been cited by other articles:
Elazary, R., Schlager, A., Appelbaum, L., Zamir, G., Nir, I.
(2009). Renal clear cell carcinoma emerging in a transplanted kidney 3 years after return to dialysis. Case report and review of the literature. NDT Plus
2: 476-478
[Abstract][Full Text]
Hui, R. L, Lide, W., Chan, J., Schottinger, J., Yoshinaga, M., Millares, M.
(2009). Association Between Exposure to Topical Tacrolimus or Pimecrolimus and Cancers. The Annals of Pharmacotherapy
43: 1956-1963
[Abstract][Full Text]
Bresson, D., von Herrath, M.
(2009). Immunotherapy for the Prevention and Treatment of Type 1 Diabetes: Optimizing the path from bench to bedside. Diabetes Care
32: 1753-1768
[Full Text]
Mudge, G. H. Jr
(2007). Sirolimus and Cardiac Transplantation: Is It the "Magic Bullet"?. Circulation
116: 2666-2668
[Full Text]
Gerrits, J. H., van de Wetering, J., Postma, S., Drabbels, J. J. M., Vaessen, L. M. B., IJzermans, J. N. M., Rischen, J., Claas, F. H. J., Weimar, W., van Besouw, N. M.
(2007). Stable T-cell reactivity after successful tapering of azathioprine in HLA-identical living-related kidney transplant recipients despite minor histocompatibility antigen mismatches. Nephrol Dial Transplant
22: 353-361
[Abstract][Full Text]
Djamali, A., Samaniego, M., Muth, B., Muehrer, R., Hofmann, R. M., Pirsch, J., Howard, A., Mourad, G., Becker, B. N.
(2006). Medical Care of Kidney Transplant Recipients after the First Posttransplant Year. CJASN
1: 623-640
[Abstract][Full Text]