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Volume 352:1384-1385 March 31, 2005 Number 13
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Fecal DNA for Colorectal-Cancer Screening

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 by Woolf, S. H.
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 by Imperiale, T. F.
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To the Editor: Although comparing the performance of a test of fecal DNA with that of a fecal occult-blood test is appealing, it would have been better if Imperiale et al. (Dec. 23 issue)1 had chosen to use fecal occult-blood tests with higher sensitivity, such as tests that measure hemoglobin with an enhancer, which allows the detection of lower levels of peroxidase, fluorimetric tests, and immunochemical tests. An immunochemical test has a sensitivity that ranges from 69 percent to 97 percent.2,3 This test has been chosen as the reference test in Japan, where its use has been shown to be . . . [Full Text of this Article]




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