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Correspondence
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Volume 352:1496-1497 April 7, 2005 Number 14
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Immune Signatures in Follicular Lymphoma

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 by Dave, S. S.
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To the Editor: The recent article by Dave et al. (Nov. 18 issue)1 is an important study correlating gene expression with survival in follicular lymphoma. My colleagues and I have reexamined their findings.

Analysis with the use of standard tools such as Significance Analysis of Microarrays (SAM) suggests that there is little or no predictive power in these data. With help from the authors and after considerable effort, we reconstructed their analysis. Dave et al. divided their data at random into equal-sized training and test sets, applied a detailed model-fitting recipe to the training set, and finally evaluated the model's . . . [Full Text of this Article]


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