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Previous Volume 352:1565-1577 April 14, 2005 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The opening of the Panama Canal in 1914 initiated an era in which efforts to control malaria were aimed at the anopheline mosquito. The World Health Organization's Global Malaria Eradication Campaign in the 1950s and 1960s marked the apex of these efforts. The use of dichlorodiphenyltrichloroethane (DDT) rid vast areas of endemic malaria virtually everywhere except in sub-Saharan Africa. The eradication strategy was abandoned in 1969, because it came to be considered logistically, socially, and politically impractical, especially given public concern about the effects of DDT on the environment. It took two decades and a global resurgence of malaria before . . . [Full Text of this Article]

Plasmodia

Extrinsic Determinants of Drug Effectiveness

Availability

Adherence

Counterfeit and Substandard Drugs

Intrinsic Determinants of Drug Effectiveness

Stage Specificity

Parasite Burden

Pharmacokinetics

Safety and Tolerability

Immunity

Resistance

Drug Resistance

Chloroquine

Sulfadoxine–Pyrimethamine

Mefloquine

Quinine

Primaquine

Combined Therapies against Resistance

Summary

Source Information

From the U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.

Address reprint requests to Dr. Baird at the American Embassy, FPO AP 96520, United States, or at baird@namru2.org.

Related Letters:

Effectiveness of Antimalarial Drugs
Gerrish S. J., De Koning L., Smego R. A. Jr., Croft A. M., Beer M. D., Herxheimer A., Baird J. K.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:420-422, Jul 28, 2005. Correspondence

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