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Volume 352:1603-1605 April 14, 2005 Number 15
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C-Reactive Protein Levels and Outcomes after Statin Therapy

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 by Ridker, P. M
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To the Editor: Ridker and colleagues (Jan. 6 issue)1 suggest that statin therapy be targeted to achieve a C-reactive protein (CRP) level of less than 2.0 mg per liter in patients with a recent acute coronary syndrome. Having examined the data presented in Table 1 of the article, we question this conclusion. After adjustment for known cardiac risk factors, the relative risk of recurrent coronary events was appreciably increased only in patients whose CRP level was in the highest quartile (>4.2 mg per liter). Patients whose CRP level was in the second or third quartile (0.9 to 4.2 mg per . . . [Full Text of this Article]


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