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Previous Volume 352:1616-1617 April 14, 2005 Number 15 Next

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(Cambridge Law, Medicine and Ethics.) By Ruth Macklin. 280 pp. New York, Cambridge University Press, 2004. $90 (cloth); $39.99 (paper). ISBN 0-521-83388-4 (cloth); 0-521-54170-0 (paper).

The controversy at the center of this book regarding the use of placebo in trials in developing countries came to light in 1997. The studies in question were evaluating the efficacy of zidovudine in the prevention of perinatal transmission of HIV, even though the drug had already been proved effective. The dispute filled hundreds of articles in medical journals and the lay press, and it led the public to question the existence of ethical guidelines in research and their application in developing countries.

As some contenders in the debate provocatively asked, were these studies in Africa or Asia not merely . . . [Full Text of this Article]

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