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Clinical Implications of Basic Research
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Volume 352:1815-1816 April 28, 2005 Number 17
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Platelet-Derived Growth Factor CC — A Clinically Useful Angiogenic Factor at Last?
Stefanie Dimmeler, Ph.D.

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Impaired vascularization that limits the supply of oxygen to tissue results in ischemic heart disease or peripheral arterial occlusive disease — potentially fatal conditions. Cardiologists therefore seek strategies to augment the blood supply, whereas cancer researchers focus on the opposite: preventing tumor growth by blocking tumor vascularization. And so efforts have focused on unraveling the molecular mechanisms that underlie postnatal vascularization. The identification of growth factors with positive or negative effects on the formation of blood vessels is one branch of this research. Along these lines, Li and colleagues1 have reported that a member of the platelet-derived growth factor (PDGF) . . . [Full Text of this Article]


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From the Department of Molecular Cardiology, University of Frankfurt, Frankfurt, Germany.



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