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Previous Volume 352:1819-1820 April 28, 2005 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Falini et al. (Jan. 20 issue)¹ report an abnormal cytoplasmic localization of nucleophosmin (NPM) in 35 percent of specimens from patients with acute myelogenous leukemia. In these patients the NPM gene was mutated, which resulted in a frame shift. The authors state that tryptophan residues at positions 288 and 290 of NPM played a role in the cytoplasmic translocation of NPM. However, these residues are responsible only for nucleolar localization of NPM, not for cytoplasmic localization.² We found a motif containing leucine-valine residues, known as the nuclear-export-signal (NES) motif, in the C-terminal of mutated NPMs A to . . . [Full Text of this Article]

This article has been cited by other articles:

• Falini, B., Nicoletti, I., Bolli, N., Martelli, M. P., Liso, A., Gorello, P., Mandelli, F., Mecucci, C., Martelli, M. F. (2007). Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. haematol 92: 519-532 [Abstract] [Full Text]