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Previous Volume 352:1847-1850 May 5, 2005 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Regulation of water homeostasis is of vital importance for all terrestrial organisms. In most mammals, including humans, the maintenance of water balance is critically dependent on water intake, the sensation of thirst, and the regulation of water excretion in the kidney, which is under the control of the antidiuretic hormone arginine vasopressin (AVP).¹ In the past decade, our insight into the AVP-mediated renal concentration mechanism has substantially improved with the elucidation of the roles of crucial molecular players in this process. The identification of disease-causing genes in hereditary disorders of water balance has been extremely helpful in identifying these pivotal . . . [Full Text of this Article]

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Dr. Knoers is a professor of clinical genetics at the Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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