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Previous Volume 352:1899-1912 May 5, 2005 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Psoriasis, a common inflammatory skin disorder, has received attention as a target for new pathogenesis-oriented biologic therapies. In this article, we review the genetic, clinical, and pathogenic aspects of psoriasis and discuss their implications for new therapies.

Epidemiologic and Genetic Features

Though psoriasis is a common skin disease, its definition by Ferdinand von Hebra as a distinct entity dates back only to the year 1841, and estimates of its prevalence — around 2 percent, according to standard textbooks — stem from only a few population-based studies. Perhaps the most comprehensive field study was performed in the Faroe Islands, where 2.8 percent of the inhabitants . . . [Full Text of this Article]

Clinical and Histopathological Features

Immunopathogenesis

Cytokines, Chemokines, and Adhesion Molecules

Therapy

Source Information

From the Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, and the Department of Dermatology, University of Würzburg, Würzburg (M.P.S.); and the Department of Dermatology, University of Frankfurt, Frankfurt (W.-H.B.) — both in Germany.

Address reprint requests to Dr. Schön at the Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, Julius Maximilians University, Versbacher Str. 9, 97078 Würzburg, Germany, or at michael.schoen@virchow.uni-wuerzburg.de.

Related Letters:

Psoriasis
Madariaga M. G., Naldi L., Chatenoud L., Khan S., Schön M. P., Boehncke W.-H.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:848-850, Aug 25, 2005. Correspondence

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