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During the past 50 years, the field of neonatal immunology has been influenced by such dogmas as "The neonatal age is a window of time when tolerance develops," and "Neonatal immune cells are unresponsive because they are immature." Yet, many questions have been left unanswered: What type of antigen induces immunologic tolerance instead of immunity in neonates? Are neonatal immune cells truly immature? How does neonatal immunity differ from adult immunity? How can safe and effective vaccines for neonates be created? Constantin Bona addresses some of these questions in this book.
After an introduction outlining the elements of the immune
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