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Because the structural role of the skeletal system is obvious, and because the hardness of mineralized bone matrix and the prolonged duration of adult bone mass emphasize its solidity, the dynamic and multifunctional nature of the skeleton are not an observer's first impression. With the World Health Organization's Decade of Bone and Joint Disease report and the 2004 U.S. Surgeon General's report on bone health and osteoporosis, we are reminded of the prevalence and cost of postmenopausal osteoporosis and fractures, cancer metastases to bone, and a host of endocrine and genetic disorders that have a primary impact on cartilage and
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