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Previous Volume 352:2136 May 19, 2005 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Kobayashi et al. (Feb. 24 issue)¹ report that a second mutation in the gene encoding the epidermal growth factor receptor (EGFR), one resulting in a threonine-to-methionine substitution at amino acid position 790 (T790M), was associated with acquired resistance to gefitinib in their patient and that this mutant gene had been absent from the primary non–small-cell lung cancer. In a reanalysis of the data from the 397 subjects we have previously described,^2,3 we identified two women who had never smoked who had non–small-cell lung cancer and harbored two EGFR mutations — T790M and a leucine-to-arginine substitution . . . [Full Text of this Article]

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