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Previous Volume 352:2359-2360 June 2, 2005 Number 22 Next

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Second edition. Edited by Andrew J. Peacock and Lewis J. Rubin. 614 pp., illustrated. London, Arnold, 2004. $198.50. ISBN 0-340-80782-2.

This second edition of Pulmonary Circulation is timely. Nine years have elapsed since its first edition in 1996, years in which we have witnessed such major scientific advances as the description of the human genome (2001) and, directly relevant to the pulmonary circulation, alteration of the gene for bone morphogenetic protein receptor type 2 (BMPR2) on chromosome 2q33. Two groups of investigators identified BMPR2 mutations in about 50 percent of familial cases and 26 percent of sporadic cases of idiopathic pulmonary arterial hypertension at the midpoint (2000) between publication of the first and second editions of Pulmonary . . . [Full Text of this Article]

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