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Previous Volume 352:2441-2443 June 9, 2005 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Calcific aortic stenosis is affecting an increasing number of patients in developed countries. It is a progressive disease that leads to a need for aortic-valve replacement when stenosis becomes severe and symptoms develop.^1,2,3,4 The growing number of valve-replacement procedures is a burden on health care systems.

The active inflammatory component of calcific aortic-valve disease has been recognized, and similarities with atherosclerotic disease have been identified. Both calcific aortic-valve disease and atherosclerosis are characterized by lipid infiltration, inflammation, neoangiogenesis, and calcification,^5,6 and the two diseases often coexist. Patients with any degree of aortic-valve disease (e.g., aortic sclerosis, mild-to-moderate stenosis, or severe . . . [Full Text of this Article]

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From the Department of Cardiology, Vienna General Hospital, Medical University of Vienna, Vienna.

Related Letters:

Lipid-Lowering Therapy in Calcific Aortic Stenosis
Chan K. L., Teo K., Newby D. E., Northridge D. B., Boon N. A.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:1066-1067, Sep 8, 2005. Correspondence

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