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Previous Volume 352:2573-2576 June 23, 2005 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In light of the success of the statin drugs, interest in preventive cardiology has shifted to new frontiers of pharmacologic intervention: defining optimal levels of low-density lipoprotein (LDL) cholesterol, inhibiting cholesterol absorption, addressing the inflammatory component of atherosclerosis, and increasing the levels of protective high-density lipoprotein (HDL) cholesterol. This last approach attracted attention last year when it was reported that a new drug, torcetrapib, could substantially increase levels of HDL cholesterol by inhibiting cholesteryl ester transfer protein.¹ The drug was heralded as a novel weapon against heart disease that could be an important clinical tool if its effect on lipids . . . [Full Text of this Article]

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Dr. Avorn is a professor of medicine at Harvard Medical School and chief of the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women's Hospital — both in Boston.

Related Letters:

Torcetrapib and Atorvastatin
Shear C. L., Hirsch R. L., Green A. M., Avorn J.
Extract | Full Text | PDF  
N Engl J Med 2005; 353:1527-1529, Oct 6, 2005. Correspondence

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