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Previous Volume 352:291-292 January 20, 2005 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Nucleophosmin (NPM) is a multifunctional phosphoprotein to which both tumor-suppressor and oncogenic functions have been attributed. Chromosomal translocations involving the NPM1 gene occur not infrequently in myeloid and lymphoid cancers. The NPM1 gene rearranges with the retinoic acid receptor (RAR) gene in acute promyelocytic leukemia and with the anaplastic lymphoma kinase (ALK) gene in a high percentage of anaplastic large-cell lymphomas. Rearrangements with the myeloid leukemia factor 1 (MLF1) gene occur in acute myelogenous leukemia (AML), chronic myelogenous leukemia, and myelodysplasia.^1,2,3 As a consequence of these translocations, the rearranged NPM1 allele encodes a fusion . . . [Full Text of this Article]

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From the Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York.

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