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Previous Volume 352:408-409 January 27, 2005 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The discovery of insulin some 80 years ago changed type 1 diabetes from an imminently lethal disease to a chronic condition, and clinical care evolved from preventing death to preventing disability. Large-scale studies defined the natural history of the development of early retinal lesions and their progression to loss of vision, leading to interventions such as laser-photocoagulation therapy to help prevent vision loss.¹ Similar work identified the fundamental importance of microalbuminuria as a sign of incipient kidney disease and defined some of the necessary interventions to prevent progression of diabetic nephropathy to impairment of renal function and end-stage renal disease.^2,3 . . . [Full Text of this Article]

Source Information

From the Divisions of Endocrinology and Metabolism (B.A.P.) and Urology (V.B.), University of Toronto, Toronto.

This article has been cited by other articles:

• Maser, R. E., Lenhard, M. J. (2005). Cardiovascular Autonomic Neuropathy Due to Diabetes Mellitus: Clinical Manifestations, Consequences, and Treatment. J. Clin. Endocrinol. Metab. 90: 5896-5903 [Abstract] [Full Text]