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Volume 352:410-414 January 27, 2005 Number 4
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Caspofungin versus Liposomal Amphotericin B for Empirical Therapy

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 by Klastersky, J.
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 by Walsh, T. J.
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To the Editor: In the important study by Walsh et al. (Sept. 30 issue),1 the most unexpected finding was the difference in response rates between the liposomal amphotericin B group and the caspofungin group among patients who had aspergillosis at baseline. The rate of response to liposomal amphotericin B (8.3 percent) is the lowest ever reported in the treatment of aspergillosis. This finding raises the question of whether there were imbalances between the treatment groups in terms of host factors (i.e., neutrophil recovery) or prior use of azole therapy, since sequential therapy with itraconazole and amphotericin B has been shown . . . [Full Text of this Article]


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