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Volume 352:414-415 January 27, 2005 Number 4
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Single-Dose Azithromycin for Trachoma

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 by Solomon, A. W.
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To the Editor: Solomon et al. (Nov. 4 issue)1 suggest that the ocular chlamydia that causes trachoma can be eliminated by a single mass antibiotic treatment. Two years after distributing oral azithromycin in a village, they identified only a single infection. The authors state that this finding "contrasts starkly" with the prediction of our mathematical model.2,3 Yes and no. We do predict that infection will eventually return after a single mass treatment. However, with 97.5 percent coverage of a moderately infected area, this return may take a long time. Our model predicts that less than 3 percent of persons will . . . [Full Text of this Article]


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