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Previous Volume 352:419-420 January 27, 2005 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In reference to the discussion of pernicious anemia in Case 30-2004 (Sept. 23 issue),¹ the practice in the United Kingdom for many years has been a regimen of four intramuscular injections of 1000 µg of hydroxocobalamin (an injectable form of vitamin B₁₂) per year in patients with pernicious anemia, usually given every three months. This treatment follows initial therapy comprising four or five 1000-µg doses given over a period of approximately four weeks. That this constitutes adequate replacement therapy is evident from widely shared experience. Pharmacokinetic evidence provides a sound basis for this practice; 500 µg . . . [Full Text of this Article]

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