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Volume 352:515-516 February 3, 2005 Number 5
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Normal Serum Vitamin D Levels

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by Kratz, A.
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To the Editor: Kratz et al. report in the October 7 issue1 the revised laboratory reference values for tests commonly ordered at the Massachusetts General Hospital. We noticed that the normative range for 25-hydroxyvitamin D is below what is now the recommended range.2,3 Historical, "normative" data for circulating 25-hydroxyvitamin D levels were based on samples from sun-deprived human subjects, who appeared to be free of disease, with normal circulating 25-hydroxyvitamin D levels assessed by plotting a Gaussian distribution.4 There are many reasons why this method is inaccurate, including such factors as race, lifestyle, use or nonuse of sunscreen, age, and . . . [Full Text of this Article]



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