One of the most challenging problems in hematology is the heterogeneousgroup of disorders that were formally defined as myelodysplasticsyndromes by the FrenchAmericanBritish CooperativeGroup in 1982. This set of disorders includes idiopathic conditionsas well as the secondary or therapy-related forms that developafter exposure to alkylating agents, radiation, or both. Idiopathicmyelodysplastic syndromes occur mainly in older persons: theincidence of these syndromes is about 5 per 100,000 personsper year in the general population, but it increases to 20 to50 per 100,000 persons per year after 60 years of age. Approximately15,000 new cases are . . . [Full Text of this Article]
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Dr. Cazzola is a professor of hematology and Dr. Malcovati a senior fellow at the University of Pavia Medical School, Pavia, Italy. Dr. Cazzola is an attending physician at the Division of Hematology, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy.
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