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Previous Volume 352:928-929 March 3, 2005 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The use of an evidence-based approach to the treatment of valvular heart disease has been hampered by the lack of rigorous data on predictors of the clinical outcome. The timing of surgery in patients with asymptomatic mitral regurgitation has been especially controversial for two reasons: the various causes of valve dysfunction and the lack of a precise measure of disease severity.¹

Clinical outcomes and approaches to treatment depend on the cause of valve dysfunction. For example, in patients with secondary mitral regurgitation owing to dilated cardiomyopathy or ischemic disease, the prognosis depends mainly on the underlying disease and valve surgery . . . [Full Text of this Article]

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From the Division of Cardiology, Department of Medicine (C.M.O.), and the Division of CardioThoracic Surgery, Department of Surgery (C.T.S.), University of Washington, Seattle.

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