To the Editor: Low birth weight resulting from intrauterinegrowth retardation is a known risk factor for the later appearanceof insulin resistance. Hofman et al. (Nov. 18 issue)1 concludethat children who are small at birth because of prematurity,regardless of their growth in utero, are also at risk for metabolicdisease.
However, the authors comment very little on the effect of interactionsbetween size at birth and early postnatal growth on subsequentinsulin sensitivity; a number of recent articles have shownthese interactions to be quite relevant.2,3,4 In this regard,it is noteworthy that children in this study . . . [Full Text of this Article]
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