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Volume 352:939-940 March 3, 2005 Number 9
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Premature Birth and Insulin Resistance

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 by Hofman, P. L.
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To the Editor: Low birth weight resulting from intrauterine growth retardation is a known risk factor for the later appearance of insulin resistance. Hofman et al. (Nov. 18 issue)1 conclude that children who are small at birth because of prematurity, regardless of their growth in utero, are also at risk for metabolic disease.

However, the authors comment very little on the effect of interactions between size at birth and early postnatal growth on subsequent insulin sensitivity; a number of recent articles have shown these interactions to be quite relevant.2,3,4 In this regard, it is noteworthy that children in this study . . . [Full Text of this Article]


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