Essential thrombocythemia is one of the chronic myeloproliferativedisorders, a heterogeneous group of diseases involving clonalhematopoietic stem cells that also includes polycythemia vera,idiopathic myelofibrosis, and chronic myelogenous leukemia.1Among these disorders, essential thrombocythemia has the mostfavorable outcome: patients with this disease have a life spanthat nearly rivals that of a healthy population matched by ageand sex.2 The principal causes of death in patients with essentialthrombocythemia are thrombosis, hemorrhage, and progressionto myelofibrosis or acute myelogenous leukemia. The myelosuppressivetherapy that prevents vascular events in essential thrombocythemiamay itself increase the risk of transformation to . . . [Full Text of this Article]
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From the Division of Hematology, Ospedali Riuniti, Bergamo, Italy.
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