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Editorial
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Volume 353:1159-1161 September 15, 2005 Number 11
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Acute Coronary Syndromes without ST-Segment Elevation — What Is the Role of Early Intervention?
William E. Boden, M.D.

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 by de Winter, R. J.
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During the past 15 years, there have been important advances in both percutaneous coronary intervention (PCI) and the pharmacotherapy of acute coronary syndromes without ST-segment elevation. Several carefully designed, randomized clinical trials have evaluated prospectively two contrasting strategies for managing these syndromes (a routine early invasive strategy and a selectively invasive strategy) and their effect on short- and long-term clinical outcomes. With the early invasive strategy, all patients undergo early coronary angiography, followed by PCI if the coronary anatomy permits. With the selectively invasive strategy, angiography and PCI are reserved for those patients who have inducible ischemia on noninvasive testing . . . [Full Text of this Article]


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From the Division of Cardiology and the Henry Low Heart Center, Hartford Hospital, Hartford, and the University of Connecticut School of Medicine, Farmington — both in Connecticut.


Related Letters:

Management of Acute Coronary Syndromes
Tarantini G., Ramondo A., Iliceto S., Newby D. E., Fox K. A., Ionescu A., Garg A., Spaulding C., Varenne O., Weber S., Costantino G., Raggi F., Montano N., Garcia-Pavia P., Aguiar-Souto P., Silva-Melchor L., de Winter R. J., Windhausen F., Tijssen J. G.P., Boden W. E.
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N Engl J Med 2005; 353:2714-2718, Dec 22, 2005. Correspondence

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