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Volume 353:1414-1415 September 29, 2005 Number 13
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A Vaccine to Prevent Herpes Zoster

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by Gilden, D. H.
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by Oxman, M.N.
-PubMed Citation
To the Editor: In Gilden's editorial1 (June 2 issue) on the study by Oxman et al.,2 the derivation of the cost-effectiveness data with regard to vaccination against varicella–zoster virus among older persons in the Shingles Prevention Study is unclear. Although benefits might accumulate over time, the long-term efficacy and side-effect profiles of the investigational vaccine are unknown. Treatment offers partial relief of symptoms but no survival advantage in an older population with a relatively short life expectancy. Over the 3.1 years of the study, the number needed to treat to prevent one case of herpes zoster appears to be 59 . . . [Full Text of this Article]



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