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Correspondence
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Volume 353:1420-1421 September 29, 2005 Number 13
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The Lessons of Vioxx

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 by Waxman, H. A.
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To the Editor: With regard to the Perspective article by Representative Waxman (June 23 issue),1 Merck initiated the Vioxx Gastrointestinal Outcomes Research (VIGOR) study to evaluate the gastrointestinal safety of Vioxx as compared with naproxen and sought a change in the Food and Drug Administration (FDA) label on the basis of its results. The cardiovascular results of this study were widely discussed on television, in newspapers, and in medical journals. Until the FDA label change, and consistent with Merck's long-standing policies, Merck instructed its sales force not to initiate discussions about VIGOR but to submit physicians' questions about the cardiovascular . . . [Full Text of this Article]




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