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Previous Volume 353:1529-1530 October 6, 2005 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The case described by Medoff et al. (June 9 issue)¹ and a similar one published in the Journal eight years ago² illustrate how rapidly the acute respiratory distress syndrome (ARDS) related to sickle cell anemia can become irreversible. In the current case, aggressive transfusions and exchange transfusions, which are the specific treatment for sickle cell disease–related ARDS,³ were ineffective 25.5 hours after severe hypoxemia was first detected (5.5 hours after the first admission). In the previously published case, exchange transfusions were performed 24 to 48 hours after the initial documentation of the values for oxygen saturation and . . . [Full Text of this Article]

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