Hypoxic–ischemic encephalopathy is an important causeof death and disability in full-term infants. The incidenceof moderate or severe hypoxic–ischemic encephalopathyhas remained essentially unchanged over the past 20 years, at1.5 to 2 per 1000 live births in the United States. Approximately15 to 20 percent of these infants will die, and 20 to 25 percentof those who survive will be disabled.1,2 Prevention is problematic,as the initiating event may occur before the onset of labor,and there are no proven effective therapies.
Brain injury is a process that begins with a hypoxic–ischemicevent and evolves after resuscitation. . . . [Full Text of this Article]
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From the Division of Neonatology, Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque.
Related Letters:
Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy
Polderman K. H., Girbes A. R.J., Nelson K. B., Leviton A., Gluckman P. D., Gunn A. J., Wyatt J. S., Shankaran S., Laptook A. R., the National Institute of Child Health and Human Development Neonatal Research Network
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N Engl J Med 2006;
354:1643-1645, Apr 13, 2006.
Correspondence
This article has been cited by other articles:
Wilkinson, D. J., Casalaz, D., Watkins, A., Andersen, C. C., Duke, T.
(2007). Hypothermia: A Neuroprotective Therapy for Neonatal Hypoxic-Ischemic Encephalopathy. Pediatrics
119: 422-423
[Full Text]
Polderman, K. H., Girbes, A. R.J., Nelson, K. B., Leviton, A., Gluckman, P. D., Gunn, A. J., Wyatt, J. S., Shankaran, S., Laptook, A. R., the National Institute of Child Health and Human D,
(2006). Hypothermia for Neonates with Hypoxic-Ischemic Encephalopathy. NEJM
354: 1643-1645
[Full Text]
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