Edited by Matcheri Keshavan, James Kennedy, and Robin Murray. 488 pp., illustrated. Cambridge, England, Cambridge University Press, 2004. $150. ISBN 0-521-82331-5.
This multiauthored book covers a broad range of topics relatedto neurodevelopment and psychosis. In its current form, theneurodevelopmental hypothesis of schizophrenia proposes thatpathogenic mechanisms operate long before the first episodeof psychosis, particularly before birth or during early postnatallife. The hypothesis has heuristic value, but it has provedto be difficult to test; the interpretation of some experimentalresults is controversial, and the lack of appropriate experimentaldesign and replication has been a frequent problem. The hypothesishas also been criticized because of the long asymptomatic periodbetween early development and the onset of psychosis —. . . [Full Text of this Article]
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